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BioPrime
Accelerate Drug Discovery with Verified Molecular Docking
BioPrime v4.0 "Golden" is a physics-based molecular docking platform featuring a 25-dimensional feature set (16 inherited + 9 new) and a novel Three-Phase Funnelization approach: Neighborhood (burial scoring + H-bond networks), Key-in-Lock (pivot residue identification + steric gating with 80% pivot kill rate), and Gasket (induced fit + desolvation penalty). Validated against 10 targets — HIV Protease, SARS-CoV-2 Mpro, Thrombin, EGFR, CDK2, p38 MAPK, Beta-2 Adrenergic, Adenosine A2A, Estrogen Receptor, and RXR — with R² = 0.73 correlation to experimental binding affinities. Supports DePIN distributed worker nodes and BSV blockchain anchoring for immutable proof of computation.
0%
Accuracy Improvement
v3.2 to v4.0 "Golden"
R² = 0
Docking Correlation
vs experimental binding affinities
0
Validated Targets
HIV Protease, EGFR, SARS-CoV-2 Mpro, and 7 more
0
Feature Dimensions
16 inherited + 9 new in v4.0
Key Features
Three-Phase Funnelization
25-dimensional scoring across Neighborhood → Key-in-Lock → Gasket progressive refinement with burial depth, H-bond networks, and desolvation penalties
Multi-Target Validation
Validated across 10 targets: HIV Protease, SARS-CoV-2 Mpro, Thrombin, EGFR, CDK2, p38 MAPK, Beta-2 Adrenergic, Adenosine A2A, Estrogen Receptor, RXR
Pivot Residue ID
Automatic identification of critical binding site residues with 80% pivot kill rate for efficient screening
Induced Fit Modeling
Conformational flexibility with desolvation penalty calculations
BSV Blockchain Anchoring
Immutable proof of computation for every docking run, enabling reproducible and verifiable drug discovery
DePIN Worker Nodes
Distributed worker architecture for decentralized high-throughput molecular screening
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Tech Stack
Python
Core Language
RDKit
Cheminformatics
CUDA
GPU Acceleration
DSC-1 Engine
Optimization
BSV Blockchain
Verification
PostgreSQL
Database
Redis
Caching
Use Cases
Drug candidate screeningBinding affinity predictionLead optimizationVirtual high-throughput screening
Related Research
Published research connected to this product.
Ready to try BioPrime?
45% accuracy improvement over previous generation, validated across 10 drug targets. Every docking result blockchain-verified for regulatory compliance and reproducibility.