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Livetopogrammar.originneural.ai
TopoGrammar
Clinical-Grade Genome Analysis in Under 5 Seconds
TopoGrammar v1.0.0 applies grammar-aware computational methods to three-dimensional genome structure analysis with 8 analysis types (each with credit costs) and WebSocket job streaming. It reclassifies Variants of Uncertain Significance (VUS) with 93% confidence following ACMG guidelines, detects Topologically Associating Domains (TADs) with F1=0.91 (outperforming HiCCUPS), achieves Neo-Loop Detection with 95% sensitivity, and TF Binding Prediction with AUROC=1.0 (+6% vs DeepSEA). Integrates BioPrime v4.0 for genome-to-drug candidate discovery pipeline in under 5 seconds. Secured with E2 Identity PQC authentication.
0%
VUS Reclassification
Confidence following ACMG guidelines
F0 = 0.91
TAD Detection
Outperforms HiCCUPS
AUROC = 0
TF Binding
+6% vs DeepSEA baseline
<0s
Pipeline Speed
Genome-to-drug pipeline with BioPrime
Key Features
Grammar-Aware Analysis
Structural grammar rules applied to 3D genome topology across 8 analysis types
VUS Reclassification
ACMG-compliant variant reclassification with 93% confidence
Neo-Loop Detection
95% sensitivity for neo-loop identification in cancer genomes
TF Binding Prediction
AUROC=1.0 transcription factor binding prediction, outperforming DeepSEA by 6%
Genome-to-Drug Pipeline
End-to-end from genomic variant to drug target in under 5 seconds via BioPrime v4.0 integration
PQC Authentication
E2 Identity post-quantum cryptographic authentication for all API access
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Tech Stack
Python
Core Language
PyTorch
ML Framework
Cooler
Hi-C Data
DSC-1 Engine
Optimization
Prisma
ORM
Next.js
Frontend
Stripe
Billing
Use Cases
Clinical variant interpretationStructural variant analysisGene regulation researchPrecision medicine
Related Research
Published research connected to this product.
Ready to try TopoGrammar?
Reclassify Variants of Uncertain Significance with 93% confidence. Full genome-to-drug-candidate pipeline in under 5 seconds via BioPrime integration.